The Pathology of Hyperthyroidism

Front Endocrinol (Lausanne). 2018 Dec 3:9:737. doi: 10.3389/fendo.2018.00737. eCollection 2018.


This article reviews those pathologic lesions which are associated with clinical and/or biochemical hyperthyroidism. Beginning with the descriptive pathology of classical Graves' disease and the less common toxic nodular goiter and hyper-functioning thyroid nodules, this paper describes the effects of non-thyroidal hormones, glandular function (including pituitary and hypothalamic lesions), ectopic production of thyroid stimulating proteins by non-thyroidal neoplasms, exogenous drug reactions causing hyper-function and finally conditions associated with a mechanic- destructive cause of hyperthyroidism.

Keywords: Graves' disease; drug reactions; ectopic hyperthyroidism; hyperfunctioning nodules; hyperthyroidism; mechanico-destructive; non-hyperthyroid; thyrotoxicosis.

Publication types

  • Review