Pycnogenol®: supplementary management of symptomatic osteoarthritis with a patch. An observational registry study

Minerva Endocrinol. 2019 Mar;44(1):97-101. doi: 10.23736/S0391-1977.18.02820-1.

Abstract

Background: The aim of the present observational registry study was to evaluate the efficacy of a thin polycarbonate patch of Pycnogenol® in alleviating symptoms of knee arthrosis, in comparison to the standard management usually applied to treat osteoarthritis (OA).

Methods: A total of 67 subjects were included in the registry: 34 formed the control group, and 33 entered the active management group in which the Pycnogenol® patch was used. Two Pycnogenol® patches were used every day for three weeks. Each patch contains 110 mg Pycnogenol®. All patients included in this registry suffered from osteoarthritis of the knee.

Results: Results from this study show that Pycnogenol® patch allows faster improvement in OA symptoms, with a decrease in the use of non-steroidal anti-inflammatory drugs and other painkillers. Pycnogenol® patch significally reduced C reactive protein and ESR.

Conclusions: Pycnogenol® patch was effective in controlling mild to moderate pain and inflammations and its related symptoms in subjects with knee OA over a period of three weeks.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Female
  • Flavonoids / administration & dosage*
  • Flavonoids / therapeutic use*
  • Humans
  • Inflammation / drug therapy
  • Knee
  • Male
  • Middle Aged
  • Osteoarthritis / drug therapy*
  • Pain / drug therapy
  • Plant Extracts / administration & dosage*
  • Plant Extracts / therapeutic use*
  • Registries
  • Transdermal Patch
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Flavonoids
  • Plant Extracts
  • pycnogenols