Surgical Site Infections Caused by Highly Virulent Methicillin-Resistant Staphylococcus aureus Sequence Type 398, China

Emerg Infect Dis. 2019 Jan;25(1):157-160. doi: 10.3201/eid2501.171862.

Abstract

We identified 2 methicillin-resistant Staphylococcus aureus strains of sequence type 398 from surgical site infections in China. Genetic analysis and clinical data from these strains suggested that they were human-related but sporadic. Hemolysis analysis and mouse-skin infection models indicated a high virulence potential for these strains.

Keywords: China; MRSA; MRSA and other staphylococci; ST398; antimicrobial resistance; bacteria; core genome MLST; methicillin-resistant Staphylococcus aureus; surgical site infection; virulence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Typing Techniques
  • China
  • Drug Resistance, Bacterial / genetics*
  • Female
  • Humans
  • Male
  • Methicillin / pharmacology
  • Methicillin-Resistant Staphylococcus aureus / genetics*
  • Methicillin-Resistant Staphylococcus aureus / pathogenicity
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Middle Aged
  • Multilocus Sequence Typing
  • Staphylococcal Infections / microbiology*
  • Surgical Wound Infection / microbiology*
  • Virulence / genetics*
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Methicillin