Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States

Emerg Infect Dis. 2019 Jan;25(1):148-152. doi: 10.3201/eid2501.180352.


Recent parechovirus A3 (PeV-A3) outbreaks in Australia suggest lower population immunity compared with regions that have endemic PeV-A3 circulation. A serosurvey among populations in the Netherlands, the United States, and Australia before and after the 2013 Australia outbreak showed high PeV-A3 neutralizing antibody prevalence across all regions and time periods, indicating widespread circulation.

Keywords: Australia; Picornaviruses; United States; neutralizing antibody; outbreak; parechovirus A3; seroepidemiology; seroprevalence; the Netherlands; viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood*
  • Australia / epidemiology
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Disease Outbreaks*
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Netherlands / epidemiology
  • Parechovirus / immunology*
  • Picornaviridae Infections / epidemiology*
  • Picornaviridae Infections / virology
  • Seroepidemiologic Studies
  • United States / epidemiology
  • Young Adult


  • Antibodies, Neutralizing
  • Antibodies, Viral