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, 89 (8-S), 53-57

Non-invasive Method for the Assessment of Gastric Acid Secretion


Non-invasive Method for the Assessment of Gastric Acid Secretion

Chiara Miraglia et al. Acta Biomed.


Methods for the measure of gastric acid secretion include invasive and non-invasive tests. The gold-standard to measure the acid output is the collection of gastric after in basal condition (Basal Acid Output, B.A.O.) and after an i.m. injection of pentagastrin (Maximal Acid Output, M.A.O.). However, direct measurement of gastric acid production is out of order in clinical practice, but many GI symptoms are claimed to be related with acid disorders and empirically cured. Hypochlorhydria is associated with precancerous conditions such as chronic atrophic gastritis (CAG). Acid measurement with non-invasive methods (pepsinogens) is supported by international guidelines.

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    1. Di Mario F, Goni E. Gastric acid secretion: Changes during a century. Best Practice & Research Clinical Gastroenterology. 2014;28(6):953–965. - PubMed
    1. Cook GC. Infective gastroenteritis and its relationship to reduced gastric acidity. Scand J Gastroenterol Suppl. 1985;111:17–23. - PubMed
    1. Giannella RA, Broitman SA, Zamcheck N. Influence of gastric acidity on bacterial and parasitic enteric infections. A perspective. Ann Intern Med. 1973;78:271–6. - PubMed
    1. Sack GH, Jr, Pierce NF, Hennessey KN, Mitra RC, Sack RB, Mazumder DN. Gastric acidity in cholera and noncholera diarrhoea. Bull World Health Organ. 1972;47:31–6. - PMC - PubMed
    1. Martinsen T. C, Bergh K, Waldum H. L. Gastric juice: a barrier against infectious diseases. Basic & clinical pharmacology & toxicology. 2005;96(2):94–102. - PubMed

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