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Review
. 2018 Dec 17;89(8-S):88-92.
doi: 10.23750/abm.v89i8-S.7921.

Clinical Manifestations of Chronic Atrophic Gastritis

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Free PMC article
Review

Clinical Manifestations of Chronic Atrophic Gastritis

Kryssia Isabel Rodriguez-Castro et al. Acta Biomed. .
Free PMC article

Abstract

Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors. Microcytic, hypochromic anemia frequently precedes the development of megaloblastic, vitamin B12-associated anemia. Moreover, vitamin B12 deficiency,may cause elevation of homocysteine, with an increase in the cardiovascular risk, and may be associated with neurological manifestations, mainly characterized by spinal cord demyelination and atrophy, with ensuing sensory-motor abnormalities. Gastrointestinal manifestations seem to be associated with non-acid reflux and tend to be non-specific.

Figures

Figure 1.
Figure 1.
Clinical manifestations of chronic atrophic gastritis (CAG)

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References

    1. Neumann W. L, Coss E, Rugge M, Genta R. M. “Autoimmune atrophic gastritis-pathogenesis, pathology and management,”. Nature Reviews Gastroenterology and Hepatology. 2013 - PubMed
    1. Lahner E, et al. “Occurrence and Risk Factors for Autoimmune Thyroid Disease in Patients with Atrophic Body Gastritis,”. Am. J. Med. 2008 - PubMed
    1. Lahner E, et al. “Reassessment of intrinsic factor and parietal cell autoantibodies in atrophic gastritis with respect to cobalamin deficiency,”. Am. J. Gastroenterol. 2009 - PubMed
    1. Carabotti M, Lahner E, Esposito G, Sacchi M. C, Severi C, Annibale B. “Upper gastrointestinal symptoms in autoimmune gastritis A cross-sectional study,”. Med. (United States) 2017 - PMC - PubMed
    1. Rugge M, et al. “Gastritis staging in clinical practice: The OLGA staging system,”. Gut. 2007 - PMC - PubMed

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