Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

Clin Infect Dis. 2019 May 30;68(12):2114-2116. doi: 10.1093/cid/ciy973.


In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.

Keywords: azithromycin; childhood mortality; sub-Saharan Africa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Azithromycin / administration & dosage*
  • Child Mortality*
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant Mortality
  • Infant, Newborn
  • Male
  • Mass Drug Administration
  • Time Factors
  • Trachoma / drug therapy*
  • Trachoma / epidemiology
  • Trachoma / mortality*


  • Anti-Bacterial Agents
  • Azithromycin

Associated data