Signal Transduction: Magnesium Manifests as a Second Messenger

Alessandra Stangherlin; John S O'Neill

doi:10.1016/j.cub.2018.11.003

Signal Transduction: Magnesium Manifests as a Second Messenger

Curr Biol. 2018 Dec 17;28(24):R1403-R1405. doi: 10.1016/j.cub.2018.11.003.

Authors

Alessandra Stangherlin¹, John S O'Neill²

Affiliations

¹ MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
² MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: oneillj@mrc-lmb.cam.ac.uk.

PMID: 30562536
DOI: 10.1016/j.cub.2018.11.003

Abstract

Mg²⁺ is an essential ion for the cell but whether it can act as a bona fide second messenger has long been questioned. A recent study supports this hypothesis and shows a signalling role for Mg²⁺ in GABA-mediated neuronal maturation.

Publication types

Comment

MeSH terms

Cytoplasm
Magnesium*
Second Messenger Systems*
Signal Transduction
gamma-Aminobutyric Acid

Substances

gamma-Aminobutyric Acid
Magnesium

Grants and funding

MC_UP_1201/4/MRC_/Medical Research Council/United Kingdom