Signal Transduction: Magnesium Manifests as a Second Messenger

Curr Biol. 2018 Dec 17;28(24):R1403-R1405. doi: 10.1016/j.cub.2018.11.003.


Mg2+ is an essential ion for the cell but whether it can act as a bona fide second messenger has long been questioned. A recent study supports this hypothesis and shows a signalling role for Mg2+ in GABA-mediated neuronal maturation.

Publication types

  • Comment

MeSH terms

  • Cytoplasm
  • Magnesium*
  • Second Messenger Systems*
  • Signal Transduction
  • gamma-Aminobutyric Acid


  • gamma-Aminobutyric Acid
  • Magnesium