Implementation of the cobas Liat influenza point-of-care test into an emergency department during a high-incidence season: a retrospective evaluation following real-world implementation

J Youngs; Y Iqbal; S Glass; P Riley; C Pope; T Planche; D Carrington

doi:10.1016/j.jhin.2018.12.008

Implementation of the cobas Liat influenza point-of-care test into an emergency department during a high-incidence season: a retrospective evaluation following real-world implementation

J Hosp Infect. 2019 Mar;101(3):285-288. doi: 10.1016/j.jhin.2018.12.008. Epub 2018 Dec 16.

Authors

J Youngs¹, Y Iqbal², S Glass³, P Riley⁴, C Pope⁵, T Planche⁵, D Carrington⁴

Affiliations

¹ Infection Care Group, St George's University Hospitals NHS Foundation Trust, London, UK. Electronic address: youngs.jonathan@gmail.com.
² Department of Emergency Medicine, St George's University Hospitals NHS Foundation Trust, London, UK.
³ Department of Microbiology, East Kent Hospitals University NHS Foundation Trust, Ashford, UK.
⁴ Infection Care Group, St George's University Hospitals NHS Foundation Trust, London, UK.
⁵ Infection Care Group, St George's University Hospitals NHS Foundation Trust, London, UK; Institute of Infection, St George's University of London, London, UK.

Abstract

The cobas Liat influenza A/B and respiratory syncytial virus (RSV) assay (Liat) was used in the adult emergency department of a large London hospital from 21^st January 2018 to 14^th April 2018. Influenza was detected in 308 of 1027 (30%) samples tested; influenza A in 157 (15.3%), influenza B in 149 (14.5%) and RSV in 28 (2.7%). When compared against Fast Track Diagnostics Respiratory Pathogens 21 multiplex polymerase chain reaction and Cepheid Xpert Xpress Flu/RSV assay, Liat performance for the detection of influenza A or B was: sensitivity 85% [95% confidence interval (CI) 76-92)], specificity 98% (95% CI 97-99), negative predictive value 94% (95% CI 92-96) and positive predictive value 95% (95% CI 91-97).

Keywords: Infection control; Influenza virus A; Influenza virus B; Point-of-care technology; Polymerase chain reaction; Rapid diagnostic tests.

Publication types

Comparative Study
Evaluation Study

MeSH terms

Adult
Diagnostic Tests, Routine / methods*
Emergency Service, Hospital*
Humans
Incidence
Influenza A virus / isolation & purification
Influenza B virus / isolation & purification
Influenza, Human / diagnosis*
London
Point-of-Care Systems*
Predictive Value of Tests
Respiratory Syncytial Virus Infections / diagnosis*
Respiratory Syncytial Viruses / isolation & purification
Retrospective Studies
Sensitivity and Specificity