Scoring systems for allergies and asthma in clinical research and practice

Allergy Asthma Proc. 2019 Mar 1;40(2):93-102. doi: 10.2500/aap.2019.40.4196. Epub 2018 Dec 18.


Background: Scoring systems are increasingly being developed for various diseases, including asthma and allergic disorders, with the objective of improving the classification of disease severity and the assessment of efficacy of therapeutic modalities. Objective: This review provided concise summaries of published scoring systems used for allergic rhinitis, asthma, atopic dermatitis, urticaria, Stevens-Johnson syndrome/toxic epidermal necrolysis, eosinophilic esophagitis, and systemic allergic reactions (anaphylaxis). Methods: We searched the medical literature between 1985 and 2018 for published scoring systems that have been developed and used in clinical trials or in practice for assessment of asthma and a variety of allergic disorders. Results: The scoring systems for each of these diseases were briefly presented in the text in chronological order of publication, and selected information was presented in the tables for easy comparisons. For more details, the reader should refer to the original relevant publications. Conclusion: Such assessment methods are useful for sound designing of clinical trials, fair comparisons of findings of studies, and objective measurements of patients' progress in clinical practice. The choice of using one scoring system over another would depend on its proven degree of validity, the purpose, and applicability.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Asthma / classification
  • Asthma / pathology*
  • Humans
  • Hypersensitivity / classification
  • Hypersensitivity / pathology*
  • Severity of Illness Index*