Influence of a multistrain probiotic on body composition and mood in female occupational shift workers

Appl Physiol Nutr Metab. 2019 Jul;44(7):765-773. doi: 10.1139/apnm-2018-0645. Epub 2018 Dec 19.


This study sought to investigate the effects of a multistrain probiotic on body composition, regional adiposity, and a series of associated metabolic health outcomes. Female health care workers employed on a rotating-shift schedule (n = 41) completed baseline anthropometric assessments; a fasted blood draw; questionnaires to assess anxiety, depression (Hospital Anxiety and Depression Scale), and fatigue (Chalder Fatigue Survey); and an exercise fatigue test. Identical post-tests occurred following 6 weeks of daily supplementation with placebo (PLA) or probiotics (2.5 × 109 CFU/g) containing 9 bacterial strains (PRO; Ecologic Barrier) combined with a prebiotic carrier matrix. PRO attenuated fat mass increases (change (Δ), 0.14 kg; confidence interval (CI) -0.46 to 0.75 kg) compared with PLA (Δ, 0.79 kg; CI 0.03-1.54 kg), whereas modest reductions in visceral adiposity resulted for both PRO and PLA. Metabolic biomarkers (total cholesterol, high-density lipoprotein, glucose, adiponectin, C-reactive protein, interleukin-6, leptin) were not influenced by either treatment (p > 0.05). Nonsignificant, but potentially clinically relevant, improvements in anxiety (Δ, -2.3 ± 2.63) and fatigue (Δ, -4.8 ± 5.5) were observed with PRO; exercise performance was unaffected. Results indicate a potential protective effect of probiotics against fat mass gain. Probiotics may alleviate anxiety and fatigue in shift-working females.

Keywords: fat mass; fatigue; graisse viscérale; health; infirmières; masse grasse; microbiome; nurses; santé; synbiotic; synbiotiques; visceral fat.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiposity / drug effects
  • Adult
  • Affect / drug effects*
  • Anxiety / psychology
  • Body Composition / drug effects*
  • Depression / psychology
  • Diet
  • Double-Blind Method
  • Exercise Test
  • Fatigue / psychology
  • Female
  • Humans
  • Middle Aged
  • Probiotics / pharmacology*
  • Work Schedule Tolerance / physiology*
  • Young Adult