Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec 19;13(12):e0209307.
doi: 10.1371/journal.pone.0209307. eCollection 2018.

Colorectal Cancer Survival Rates in Ghana: A Retrospective Hospital-Based Study

Affiliations
Free PMC article

Colorectal Cancer Survival Rates in Ghana: A Retrospective Hospital-Based Study

Francis Agyemang-Yeboah et al. PLoS One. .
Free PMC article

Abstract

Background: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore investigated the survival rate of colorectal cancer and its prognostic factors among patients at Komfo Anokye Teaching Hospital, Ghana.

Methodology: In this retrospective cohort study, a total of 221 patients diagnosed with CRC from 2009 to 2015 at the Surgical and Oncological units of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana were employed. The survival graphs were obtained using the Kaplan-Meier method and compared by the Log-rank test. Cox regression analysis was used to assess prognostic factors. All analyses were performed by SPSS version 22.

Results: The median survival time was 15 months 95% CI (11.79-18.21). The overall survival rate for CRC over the 5 years period was 16.0%. The survival rates at the 1st, 2nd, 3rd, 4th and 5th years were 64% 95% CI (56.2-71.1), 40% 95% CI (32.2-50.1), 21% 95% CI (11.4-30.6) 16% 95% CI (8.9-26.9) and 16% 95% CI (7.3-24.9). There was a significant difference in the survival rate of colorectal cancer according to the different stages (p = 0.0001). Family history [HR = (3.44), p = 0.029)], Chemotherapy [HR = (0.23), p = <0.0001)], BMI [HR = (1.78), p = 0.017)] and both chemo/radiotherapy (HR = (3.63), p = 0.042)] were the significant social and clinical factors influencing the overall survival. Pathological factors such as TNM tumour stage (p = 0.012), depth of tumour invasion (p = 0.036), lymph node metastasis (p = 0.0001), and distance metastasis (p = 0.001) were significantly associated with overall survival.

Conclusion: The study has clearly demonstrated that survival rate for CRC patients at KATH, Ghana is very low in a 5 years period. This is influenced by significant number of clinical and pathological prognostic factors. Identification of prognostic factors would be a primary basis for early prediction and treatment of patients with colorectal cancer.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Procedure for the selection of cases for the study.
Fig 2
Fig 2. Overall 5 year’s survival function curve in colorectal cancer patients at KATH.
Fig 3
Fig 3. Cumulative survival of CRC based on the cancer stage.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Haggar FA, Boushey RP: Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clinics in colon and rectal surgery 2009, 22(4):191 10.1055/s-0029-1242458 - DOI - PMC - PubMed
    1. Köhne C-H, Kretzschmar A, Wils J: First-Line chemotherapy for colorectal carcinoma–we are making progress. Oncology Research and Treatment 1998, 21(4):280–289.
    1. El Zouhairi M, Charabaty A, Pishvaian MJ: Molecularly targeted therapy for metastatic colon cancer: proven treatments and promising new agents. Gastrointestinal cancer research: GCR 2011, 4(1):15 - PMC - PubMed
    1. Jackson‐Thompson J, Ahmed F, German RR, Lai SM, Friedman C: Descriptive epidemiology of colorectal cancer in the United States, 1998–2001. Cancer 2006, 107(S5):1103–1111. - PubMed
    1. Boyle P, Langman J: ABC of colorectal cancer: Epidemiology. BMJ: British Medical Journal 2000, 321(7264):805 - PMC - PubMed

Grant support

There was no funding for the project.
Feedback