NLRC3 Restrains Responses to a T

Immunity. 2018 Dec 18;49(6):989-991. doi: 10.1016/j.immuni.2018.12.003.


The NOD-like receptor protein NLRC3 attenuates myeloid cell inflammatory responses. In this issue of Immunity, Uchimura et al. (2018) reveal additional T-cell-intrinsic functions for NLRC3 in restricting T cell metabolism, T helper 1 and T helper 17 cell responses, and antiviral and autoimmune responses.

Publication types

  • Comment

MeSH terms

  • Autoimmunity*
  • Carrier Proteins
  • Immunity, Innate
  • Intercellular Signaling Peptides and Proteins*
  • T-Lymphocytes


  • Carrier Proteins
  • Intercellular Signaling Peptides and Proteins