Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec 18;19(12):4109.
doi: 10.3390/ijms19124109.

Types of Gastric Carcinomas

Affiliations
Free PMC article
Review

Types of Gastric Carcinomas

Helge L Waldum et al. Int J Mol Sci. .
Free PMC article

Abstract

Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are typically localized to one of the three mucosae; cardial, oxyntic and antral. Moreover, not only the stem cell, but the ECL cell may proliferate and give rise to tumours. According to Laurén, the classification of gastric carcinomas seems to reflect biological important differences and possible different cell of origin since the two subtypes, intestinal and diffuse, do not transform into the other and show different epidemiology. The stem cell probably gives rise to the intestinal type, whereas the ECL cell may be important in the diffuse type. Elevation of gastrin may be the carcinogenic factor for Helicobacter pylori as well as the recently described increased risk of gastric cancer due to proton pump inhibitor treatment. Therefore, it is essential to determine the role of the gastrin target cell, the ECL cell, in gastric carcinogenesis. Clinical trials with gastrin antagonists could improve prognoses in those with gastrin receptor positive tumours. However, further studies on gastric carcinomas applying relative available methods and with the highest sensitivity are warranted to improve our knowledge of gastric carcinogenesis.

Keywords: classification; gastric carcinoma; gastrin; neuroendocrine cells; types of gastric carcinomas.

Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Proposed carcinogenesis for gastric carcinoma of intestinal type (From ref 19 with permission [21]).
Figure 2
Figure 2
Proposed carcinogenesis for gastric carcinomas of diffuse type (From ref 78 with permission [82]).

Similar articles

See all similar articles

Cited by 3 articles

References

    1. Kilgore S.P., Ormsby A.H., Gramlich T.L., Rice T.W., Richter J.E., Falk G.W., Goldblum J.R. The gastric cardia: Fact or fiction? Am. J. Gastroenterol. 2000;95:921–924. doi: 10.1111/j.1572-0241.2000.01930.x. - DOI - PubMed
    1. Choi E., Roland J.T., Barlow B.J., O′Neal R., Rich A.E., Nam K.T., Shi C., Goldenring J.R. Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Gut. 2014;63:1711–1720. doi: 10.1136/gutjnl-2013-305964. - DOI - PMC - PubMed
    1. Tielemans Y., Willems G., Sundler F., Håkanson R. Self-replication of enterochromaffin-like cells in the mouse stomach. Digestion. 1990;45:138–146. doi: 10.1159/000200235. - DOI - PubMed
    1. Tsolakis A.V., Portela-Gomes G.M., Stridsberg M., Grimelius L., Sundin A., Eriksson B.K., Oberg K.E., Janson E.T. Malignant gastric ghrelinoma with hyperghrelinemia. J. Clin. Endocrinol. MeTable. 2004;89:3739–3744. doi: 10.1210/jc.2003-032118. - DOI - PubMed
    1. Borrmann R. Geschwülste des Magens und Duodenums. In: Henke F., Lubarsch O., editors. Handbuch des Speziellen Pathologischen Anatomie und Histologie. Springer; Berlin, Germany: 1926.

MeSH terms

Feedback