Health-related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients

Pediatr Transplant. 2019 Mar;23(2):e13337. doi: 10.1111/petr.13337. Epub 2018 Dec 19.


Purpose: The understanding of the HRQOL issues for parent donors of children who underwent LDLT is lacking. We evaluated the HRQOL of donor and non-donor parents, described their subjective experiences and identified factors associated with lower HRQOL post-donation.

Methods: This is a cross-sectional study of parent donors whose children underwent LDLT, using SF-36v2 Health Survey to measure HRQOL, and a self-developed questionnaire to evaluate their subjective experiences.

Results: Of 32 pairs of donor and non-donor parents, 27 donor and 19 non-donor parents responded. The data of respondents were analyzed. Both donor and non-donor parents' SF-36v2 norm-based scores were average or above average as compared to the Singapore population. Donors who made lifestyle changes post-donation (adopting a healthy balanced diet, regular physical activity, quitting smoking, and moderate alcohol intake) were associated with lower GH (P = 0.009) and PF (P = 0.002) scores. Donors who took more than 3 months for full recovery had lower RP (P = 0.022) and BP scores (P = 0.038). On multivariate analysis, recipient complication of Clavien grade 3 or 4 was associated with increased RP score by 8.71 points (95% CI: 1.74-15.68), after adjusting for time taken for full recovery. Majority (88.8%) had self-reported recovery time under 6 months and returned to work within 3 months (74.0%).

Conclusions: Donors with factors potentially associated with lower HRQOL may need more support to ensure better HRQOL outcomes post-donation.

Keywords: health-related quality of life; living donor liver transplantation; non-donor parent; outcomes; parent donor; pediatric; post-donation.

MeSH terms

  • Adult
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Health Status Indicators
  • Humans
  • Linear Models
  • Liver Transplantation / psychology*
  • Living Donors / psychology*
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Parents / psychology*
  • Quality of Life / psychology*