Hypereosinophilia: a diagnostic challenge

Neth J Med. 2018 Dec;76(10):431-436.


Hypereosinophilia encompasses a broad differential diagnosis of atopy/allergic reactions, drug reactions, parasitic infections and paraneoplastic syndromes. Although mostly of limited clinical significance, hypereosinophilia can also be related to hematological malignancies. One has to be aware of the potential for secondary organ damage for example, in the case of hypereosinophilic syndrome. We present three cases with different underlying mechanisms of hypereosinophilia with a brief overview of causes, diagnostic work-up and treatment options.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Diagnosis, Differential
  • Drug-Related Side Effects and Adverse Reactions / blood
  • Eosinophilia* / diagnosis
  • Eosinophilia* / etiology
  • Eosinophilia* / physiopathology
  • Eosinophilia* / therapy
  • Hematologic Neoplasms / blood
  • Humans
  • Paraneoplastic Syndromes / blood
  • Parasitic Diseases / blood
  • Patient Care Management / methods*