New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis

J Pathol. 2019 May;248(1):6-8. doi: 10.1002/path.5220. Epub 2019 Feb 11.


Obesity and acute pancreatitis are both proinflammatory conditions. Importantly, obesity increases severity in acute pancreatitis by enhancing inflammation. In a recent issue of The Journal of Pathology, Pérez and Ruiz-Pérez et al connected obesity and pancreatitis for the first time, through the transcriptional regulator PPARγ coactivator 1α (PGC-1α). Obesity reduces pancreatic PGC-1α levels and potentiates not only oxidative but also IL-6-mediated inflammatory damage during acute pancreatitis by relieving the binding of PGC-1α to the NF-κB subunit p65. Blockade of the IL-6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC-1α/p65/IL-6 signaling in obesity and acute pancreatitis. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Keywords: NF-κBIL-6; PGC-1α; acute pancreatitis; obesity.

Publication types

  • Comment

MeSH terms

  • Carcinogenesis
  • Humans
  • NF-kappa B
  • Obesity
  • Pancreatitis*
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • United Kingdom
  • Wine*


  • NF-kappa B
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha