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Lupus Erythematosus

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–.

Lupus Erythematosus

Angel A. Justiz Vaillant et al.


The acute form of systemic lupus erythematosus (SLE) differs from the chronic form. It disseminates differently, and it is highly fatal. Kaposi was the first to recognize SLE in 1872, and then Pernet described it in 1908. Before that time, SLE was considered to be a non-fatal disfiguring skin disease. It is now to be considered a chronic inflammatory disease characterized by a course of alternating exacerbations and remissions. SLE mimics other diseases, and therefore, its diagnosis may be difficult. It is a multisystemic, autoimmune disease in which the immune system produces autoantibodies against a variety of autoantigens, for example, antinuclear antibody (ANA) and anti-blood cell antibody. It affects vital organs such as kidneys, heart, central nervous system (CNS), the skin, the lungs, the joints, and the reproductive system. Clinical criteria defined by the American Rheumatism Association (ARA) define SLE, and 4 out of the 11 criteria confirm the diagnosis.

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