The acute form of systemic lupus erythematosus (SLE) differs from the chronic form. It disseminates differently, and it is highly fatal. Kaposi was the first to recognize SLE in 1872, and then Pernet described it in 1908. Before that time, SLE was considered to be a non-fatal disfiguring skin disease. It is now to be considered a chronic inflammatory disease characterized by a course of alternating exacerbations and remissions. SLE mimics other diseases, and therefore, its diagnosis may be difficult. It is a multisystemic, autoimmune disease in which the immune system produces autoantibodies against a variety of autoantigens, for example, antinuclear antibody (ANA) and anti-blood cell antibody. It affects vital organs such as kidneys, heart, central nervous system (CNS), the skin, the lungs, the joints, and the reproductive system. Clinical criteria defined by the American Rheumatism Association (ARA) define SLE, and 4 out of the 11 criteria confirm the diagnosis.
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Antibodies Against High Mobility Group Box protein-1 (HMGB1) Versus Other Anti-Nuclear Antibody Fine-Specificities and Disease Activity in Systemic Lupus ErythematosusL Wirestam et al. Arthritis Res Ther 17, 338. PMID 26596890.We confirm that anti-HMGB1 antibodies are common in SLE and correlate with disease activity variables. Although anti-HMGB1 antibodies measured by ELISA often coincide wit …
Antibodies to Cytoplasmic Antigens in Lupus Erythematosus. Serologic Marker for Systemic DiseaseTT Provost et al. Arthritis Rheum 20 (8), 1457-63. PMID 303519. - Case ReportsSeven patients with classic cutaneous lupus erythematosus are described. Three of these patients had features satisfying four of the American Rheumatism Association (ARA) …
Rowell Syndrome in Nigeria: Systemic Lupus Erythematosus Presenting as Recurrent Erythema Multiforme in a Young WomanRO Akintayo et al. Acta Dermatovenerol Croat 27 (3), 200-201. PMID 31542069.Dear Editor, Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by diverse patterns of auto-antibody production with multi-organ affec …
Autoantibody Determination in the Diagnosis of Systemic Lupus ErythematosusBT Kurien et al. Scand J Immunol 64 (3), 227-35. PMID 16918691. - ReviewSystemic lupus erythematosus (SLE) is an autoimmune disease that usually develops in young women aged 18-50 years and is characterized by the presence of autoantibodies. …
[General and Ocular Symptoms in Systemic Lupus Erythematosus (SLE)]J Brydak-Godowska. Klin Oczna 109 (1-3), 68-70. PMID 17687918. - ReviewSystemic lupus erythematosus (SLE) is a chronic, immunologically mediated inflammatory connective tissue disorder with manifestations including various body organs (joint …