Ixodes dammini: evidence for salivary prostacyclin secretion

J Parasitol. 1988 Dec;74(6):1068-9.


Pilocarpine-induced saliva of adult Ixodes dammini ticks contained abundant amounts (523 +/- 140 ng/ml, mean +/- SE, n = 14) of 6-keto-PGF1 alpha, the stable degradation product of prostacyclin. This prostaglandin was identified by radioimmunoassay and reversed-phase chromatography. This activity may help tick feeding by preventing host hemostatic reactions, by increasing host blood flow at the tick feeding site, and by preventing leukocyte degranulation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 6-Ketoprostaglandin F1 alpha / analysis*
  • Animals
  • Dinoprostone / analysis
  • Epoprostenol / metabolism*
  • Radioimmunoassay
  • Saliva / analysis
  • Ticks / metabolism*


  • 6-Ketoprostaglandin F1 alpha
  • Epoprostenol
  • Dinoprostone