Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies

Neuron. 2018 Dec 19;100(6):1267-1269. doi: 10.1016/j.neuron.2018.12.003.


Innate immunity is increasingly recognized to contribute to the pathogenesis of neurodegenerative disorders. In this issue of Neuron, Dejanovic et al. (2018) and Litvinchuk et al. (2018) describe mechanisms by which the complement system influences tau-mediated degeneration in mouse models of tauopathy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Complement C1q
  • Mice
  • Proteome*
  • Synapses
  • Tauopathies*
  • tau Proteins


  • Proteome
  • tau Proteins
  • Complement C1q