SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)

Viruses. 2018 Dec 19;10(12):727. doi: 10.3390/v10120727.


Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats.

Keywords: WIV1-CoV; animal model; coronavirus; emerging infectious diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Chiroptera / virology*
  • Coronavirus / genetics
  • Coronavirus / physiology*
  • Coronavirus Infections / immunology
  • Coronavirus Infections / virology*
  • Disease Models, Animal
  • Male
  • Oropharynx / virology
  • RNA, Viral / genetics
  • Severe acute respiratory syndrome-related coronavirus / genetics
  • Virus Replication*


  • Antibodies, Viral
  • RNA, Viral