A multi-center, randomized controlled clinical trial of the application of a shortened protocol of long-acting Triptorelin down-regulated prior to IVF/ICSI among patients with endometriosis: A protocol

Reprod Health. 2018 Dec 20;15(1):213. doi: 10.1186/s12978-018-0639-8.

Abstract

Background: Endometriosis is the major cause of progressive pelvic pain and subfertility. Up to 50% of reproductive-age women suffer from pelvic pain. Endometriosis is a classic indication for IVF. Compared with women whose inability to procreate is caused by simple tubal infertility, women with endometriosis often have lower pregnancy rates following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The administration of gonadotrophin-releasing hormone (GnRH) agonists prior to IVF/ICSI can improve the successful pregnancy rate. Whether a briefer treatment interval would be efficacious has not been studied.

Methods/design: Eligible and consenting women will be randomly assigned to one of two treatments (one cycle of a GnRH agonist or two cycles of a GnRH agonist) prior to IVF/ICSI using a table of random numbers. The primary outcome of this trial is clinical pregnancy rate. Other outcomes include gonadotrophin (Gn) duration, the total dose of follicle-stimulating hormone (FSH) used, number of oocytes retrieved, number of embryos available for transfer, implantation rate, the abortion rate, live birth rate, and incidence of moderate-to-severe ovarian hyperstimulation. The sample size of this trial is estimated to be 421 participants for each of the two arms. Appropriate interim analyses will be conducted by a data monitoring and ethics committee (DMEC), and the final test will be an intention-to-treat analysis.

Trial registration: This trial has been assigned the following registry number: NCT03006406 .

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Birth Rate
  • Endometriosis / physiopathology*
  • Female
  • Humans
  • Infertility / drug therapy*
  • Infertility / etiology
  • Luteolytic Agents / blood
  • Luteolytic Agents / therapeutic use*
  • Pregnancy
  • Pregnancy Rate
  • Prospective Studies
  • Single-Blind Method
  • Sperm Injections, Intracytoplasmic / methods*
  • Triptorelin Pamoate / blood
  • Triptorelin Pamoate / therapeutic use*

Substances

  • Luteolytic Agents
  • Triptorelin Pamoate

Associated data

  • ClinicalTrials.gov/NCT03006406