Nucleus-Invadopodia Duo During Cancer Invasion

Trends Cell Biol. 2019 Feb;29(2):93-96. doi: 10.1016/j.tcb.2018.11.006. Epub 2018 Dec 17.

Abstract

Matrix proteolysis mediated by MT1-MMP facilitates the invasive migration of tumor cells in dense tissues, which otherwise get trapped in the matrix because of limited nuclear deformability. A digest-on-demand response has been identified, which requires nucleus-microtubule linkage through the LINC complex and triggers MT1-MMP surface-exposure to facilitate nucleus movement.

Keywords: LINC complex; MT1-MMP; centrosome; invadopodia; microtubule; tumor invasion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Movement*
  • Cell Nucleus / metabolism*
  • Extracellular Matrix / metabolism*
  • Humans
  • Lamin Type A / metabolism
  • Matrix Metalloproteinase 14 / metabolism
  • Microtubules / metabolism
  • Models, Biological
  • Neoplasm Invasiveness
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Podosomes / metabolism*

Substances

  • LMNA protein, human
  • Lamin Type A
  • Matrix Metalloproteinase 14