Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: Randomised clinical trial

Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24(1):e114-e122. doi: 10.4317/medoral.22590.

Abstract

Background: Postoperative pain is one of the most common complications. The aim of this study is to evaluate the analgesic efficacies of dexketoprofen trometamol and two different dosages of dexketoprofen trometamol + thiocolchicoside combination in the impacted third molar tooth operation.

Material and methods: This randomized, double-blind study included 75 patients who did not have any disease. Patients were assigned to 3 groups. Group 1 received 25 mg dexketoprofen trometamol + 4 mg thiocholchicoside, Group 2 received 25 mg dexketoprofen trometamol +8 mg thiocholchicoside, and Group 3 received 25 mg dexketoprofen trometamol. In each group, the analgesic medication was administered twice a day, starting 1 hour before the operation. The level of pain was assessed with VAS.

Results: Patient age varied from 18 to 36 years. Of all patients, 59.2% (n=42) were female and 40.8% (n=29) were male. Drug side effects were observed in 28.17% (n=20) of the patients. Mean 24th hour VAS score was lower in dexketoprofen trometamol + 8 mg thiocolchicoside group compared to dexketoprofen trometamol group (p<0.05). There was no statistically significant difference between the three groups regarding drug side effects (p>0.05).

Conclusions: Dexketoprofen trometamol + 8 mg thiocolchicoside combination has higher analgesic efficacy compared to dexketoprofen trometamol. More studies are needed to interpret the analgesic and anti-inflammatory effects of thiocholchicoside + dexketoprofen trometamol combination.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Analgesia*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Colchicine / administration & dosage
  • Colchicine / analogs & derivatives*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Ketoprofen / administration & dosage
  • Ketoprofen / analogs & derivatives*
  • Male
  • Molar, Third / surgery*
  • Tooth, Impacted / surgery*
  • Tromethamine / administration & dosage*
  • Young Adult

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Tromethamine
  • Ketoprofen
  • dexketoprofen trometamol
  • Colchicine
  • thiocolchicoside