Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment

Nanomedicine (Lond). 2019 Mar;14(6):727-752. doi: 10.2217/nnm-2018-0436. Epub 2018 Dec 21.


Aim: Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency.

Materials & methods: Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells.

Results: Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug.

Conclusion: Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.

Keywords: blood–brain barrier; dynamic fluidic models; glioblastoma multiforme; magnetic targeting; nutlin-3a; solid lipid nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use
  • Biological Transport
  • Blood-Brain Barrier
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Glioblastoma / drug therapy*
  • Humans
  • Imidazoles / chemistry*
  • Imidazoles / therapeutic use
  • Kinetics
  • Lipids / chemistry*
  • Magnetite Nanoparticles / chemistry*
  • Particle Size
  • Piperazines / chemistry*
  • Piperazines / therapeutic use
  • Surface Properties


  • Antineoplastic Agents
  • Drug Carriers
  • Imidazoles
  • Lipids
  • Magnetite Nanoparticles
  • Piperazines
  • nutlin 3