Treatment of corneal neovascularization with topical aflibercept in a case of exposure keratopathy following cerebellar astrocytoma surgery

Indian J Ophthalmol. 2019 Jan;67(1):145-147. doi: 10.4103/ijo.IJO_418_18.

Abstract

In this report, we report the case of a 7-year-old boy with corneal neovascularization due to exposure keratopathy following cerebellar astrocytoma surgery. Corneal surface healing was achieved with topical treatment and therapeutic contact lens, after which topical steroid was administered for stromal haze and corneal neovascularization. After 2 months of steroid therapy failed, corneal neovascularization responded well to topical aflibercept administration, showing complete regression.

Keywords: Aflibercept; anti-VEGF; corneal vascularization.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Astrocytoma / diagnosis
  • Astrocytoma / surgery*
  • Cerebellar Neoplasms / diagnosis
  • Cerebellar Neoplasms / surgery*
  • Child
  • Corneal Neovascularization / diagnosis
  • Corneal Neovascularization / drug therapy*
  • Corneal Neovascularization / etiology
  • Humans
  • Male
  • Neurosurgical Procedures / adverse effects*
  • Postoperative Complications*
  • Receptors, Vascular Endothelial Growth Factor / administration & dosage*
  • Recombinant Fusion Proteins / administration & dosage*
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Visual Acuity

Substances

  • Recombinant Fusion Proteins
  • Vascular Endothelial Growth Factor A
  • aflibercept
  • Receptors, Vascular Endothelial Growth Factor