Targeting Mammalian Translational Inhibition with Tetracyclines

Robert E Boer; John S Schneekloth Jr

doi:10.1016/j.chembiol.2018.12.006

Targeting Mammalian Translational Inhibition with Tetracyclines

Cell Chem Biol. 2018 Dec 20;25(12):1437-1438. doi: 10.1016/j.chembiol.2018.12.006.

Authors

Robert E Boer¹, John S Schneekloth Jr²

Affiliations

¹ Chemical Biology Laboratory, National Cancer Institute, Frederick MD, 21702, USA.
² Chemical Biology Laboratory, National Cancer Institute, Frederick MD, 21702, USA. Electronic address: schneeklothjs@mail.nih.gov.

PMID: 30576658
DOI: 10.1016/j.chembiol.2018.12.006

Abstract

In this issue of Cell Chemical Biology, Mortison et al. (2018) report an in-depth mechanistic study of targets of two different tetracyclines in mammalian cells. Unbiased chemoproteomics and RNA sequence mapping help identify specific ribosomal substructures bound by tetracyclines, providing insight into the therapeutic potential for tetracyclines in many diseases.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Comment

MeSH terms

Animals
Anti-Bacterial Agents*
Humans
Ribosomes
Tetracyclines*

Substances

Anti-Bacterial Agents
Tetracyclines

Grants and funding

ZIA BC011585/BC/NCI NIH HHS/United States