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. 2018 Dec 20;17(1):4.
doi: 10.3390/md17010004.

Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

Pei Wang  1   2 , Yan Cui  3   4 , Caihong Cai  5   6 , Huiqin Chen  7   8 , Yu Dai  9   10 , Pengwei Chen  11   12 , Fandong Kong  13   14 , Jingzhe Yuan  15   16 , Xinming Song  17 , Wenli Mei  18   19 , Haofu Dai  20   21
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Free PMC article

Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

Pei Wang et al. Mar Drugs. .
Free PMC article

Abstract

Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC50 values of 29.4 ± 0.35 μM, 25.6 ± 0.47 μM, and 41.7 ± 0.71 μM, respectively, whereas compound 4 exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC50 values of 14.9 ± 0.21 μM and 26.7 ± 1.1 μM, respectively. In addition, compounds 4 and 5 displayed inhibitory activity against α-glycosidase, with IC50 values of 78.2 ± 2.1 μM and 49.3 ± 10.6 μM, respectively.

Keywords: Cladosporium sp.; cytotoxicity; mangrove-derived fungus; succinimide-containing derivatives; α-glycosidase inhibitor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of compounds 1–5 from Cladosporium sp. HNWSW-1.
Figure 2
Figure 2
The key 2D NMR correlations for compound 1.
Figure 3
Figure 3
The key 2D NMR correlations for compounds 2 and 3.
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