Amphotericin B deoxycholate for relapse visceral leishmaniasis in Bangladesh: a cross-sectional study

BMC Res Notes. 2018 Dec 22;11(1):918. doi: 10.1186/s13104-018-4036-8.


Objective: Based on studies in India (as there was no studies from outside India) amphotericin B deoxycholate has been considered as a backup drug for treatment of visceral leishmaniasis. However, treatment response and adverse effect to anti-leishmanial drugs may vary across different populations and in Bangladesh the effect to amphotericin B deoxycholate for treatment of visceral leishmaniasis is still unknown. Therefore, there is a need to explore cure rate and adverse effects to amphotericin B deoxycholate to justify its use on visceral leishmaniasis patients in Bangladesh.

Result: Here we report 34 visceral leishmaniasis patients who received treatment with amphotericin B deoxycholate in the Surya Kanta Kala-azar Research Centre from December 2011 to June 2015. The dose of the treatment was 1 mg/kg body weight for 15 days followed up until 12 months after treatment. Response to amphotericin B deoxycholate treatment was excellent as all 34 patients achieved a final cure. Hypokalaemia (47%), shivering (47%), vomiting (35%) and acidity (15%) were most common adverse events. However, we did not observe any serious adverse events. Amphotericin B deoxycholate for relapse visceral leishmaniasis was found to be highly effective and safe. Our study justified to include amphotericin B deoxycholate as a second line drug for visceral leishmaniasis in Bangladesh.

Keywords: Amphotericin B deoxycholate; Bangladesh; Treatment outcome; Visceral leishmaniasis.

MeSH terms

  • Adolescent
  • Adult
  • Amphotericin B / administration & dosage
  • Amphotericin B / adverse effects
  • Amphotericin B / pharmacology*
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / adverse effects
  • Anti-Infective Agents / pharmacology*
  • Bangladesh
  • Child
  • Cross-Sectional Studies
  • Deoxycholic Acid / administration & dosage
  • Deoxycholic Acid / adverse effects
  • Deoxycholic Acid / pharmacology*
  • Drug Combinations
  • Female
  • Humans
  • Leishmaniasis, Visceral / drug therapy*
  • Male
  • Recurrence
  • Treatment Outcome


  • Anti-Infective Agents
  • Drug Combinations
  • Deoxycholic Acid
  • Amphotericin B
  • amphotericin B, deoxycholate drug combination