Hypertensive Diseases of Pregnancy Increase Risk of Readmission With Heart Failure: A National Readmissions Database Study

Mayo Clin Proc. 2019 May;94(5):811-819. doi: 10.1016/j.mayocp.2018.08.032. Epub 2018 Dec 19.


Objective: To study the association between hypertensive diseases of pregnancy and immediate postpartum development of heart failure in a large national database.

Patients and methods: Using the 2013 to 2014 National Readmissions Database, which covered admissions from January 1 through September 30 in years 2013 and 2014, we examined 90-day readmission rates in parturients with a diagnosis of hypertensive disease of pregnancy who were discharged after delivery. The primary outcome was the association between the presence of hypertensive disease of pregnancy and readmission with heart failure within 90 days of delivery discharge. Secondary outcomes included readmission mortality, time between delivery discharge and readmission, length of stay, and costs of readmission.

Results: Women with hypertensive disease of pregnancy were more likely to be readmitted with heart failure (1809 of 25,908 readmissions (7.0%) vs 2622 of 89,660 readmissions (2.9%); P<.001). This difference persisted after adjustment for potential cofounders (6.3% vs 3.1%; odds ratio, 2.15; 95% CI, 1.92-2.40; P<.001). Women with a diagnosis of heart failure at readmission were readmitted sooner (11 days vs 23 days; P<.001) and had a longer length of stay (4 days vs 3 days; P<.001) and higher costs of readmission ($10,361 vs $6977; P<.001) than did women without a diagnosis of heart failure.

Conclusion: Parturients with hypertensive disease of pregnancy were more likely to be readmitted with heart failure within 90 days of delivery. Most patients readmitted with heart failure were readmitted within 2 weeks of discharge after delivery. Patients readmitted with heart failure had substantial health care expenditures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Comorbidity
  • Databases, Factual
  • Female
  • Heart Failure / epidemiology*
  • Hospital Mortality
  • Humans
  • Hypertension, Pregnancy-Induced / epidemiology*
  • Length of Stay / economics
  • Length of Stay / statistics & numerical data*
  • Outcome Assessment, Health Care / statistics & numerical data
  • Patient Readmission / economics
  • Patient Readmission / statistics & numerical data*
  • Postpartum Period
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • Young Adult