Correlation of extracellular matrix-related gene expression with objective Fuchs endothelial corneal dystrophy severity

Clin Exp Ophthalmol. 2019 Jul;47(5):671-673. doi: 10.1111/ceo.13461. Epub 2019 Feb 14.

Authors

Mario Matthaei¹, Christoph Leitl¹, Claus Cursiefen¹, Ludwig M Heindl¹

Affiliation

¹ Department of Ophthalmology, University of Cologne, Cologne, Germany.

PMID: 30578652
DOI: 10.1111/ceo.13461

No abstract available

Publication types

Letter

MeSH terms

Aged
Collagen Type I / genetics
Collagen Type I, alpha 1 Chain
Collagen Type III / genetics
Collagen Type IV / genetics*
Corneal Edema / diagnosis
Corneal Edema / genetics
Corneal Edema / surgery
Corneal Topography
Descemet Stripping Endothelial Keratoplasty
Extracellular Matrix / metabolism
Extracellular Matrix Proteins / genetics*
Female
Fibronectins / genetics*
Fuchs' Endothelial Dystrophy / diagnosis
Fuchs' Endothelial Dystrophy / genetics*
Fuchs' Endothelial Dystrophy / surgery
Gene Expression / physiology*
Humans
Laminin / genetics*
Male
Middle Aged
RNA, Messenger / genetics
Real-Time Polymerase Chain Reaction
Slit Lamp Microscopy

Substances

COL3A1 protein, human
COL4A1 protein, human
Collagen Type I
Collagen Type I, alpha 1 Chain
Collagen Type III
Collagen Type IV
Extracellular Matrix Proteins
FN1 protein, human
Fibronectins
Laminin
RNA, Messenger
laminin gamma 1