Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

Amber Dahlin; Joanne E Sordillo; John Ziniti; Carlos Iribarren; Meng Lu; Scott T Weiss; Kelan G Tantisira; Quan Lu; Mengyuan Kan; Blanca E Himes; Eric Jorgenson; Ann Chen Wu

doi:10.1016/j.jaci.2018.11.037

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

J Allergy Clin Immunol. 2019 Apr;143(4):1633-1635. doi: 10.1016/j.jaci.2018.11.037. Epub 2018 Dec 20.

Authors

Affiliations

¹ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
² PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.
³ Division of Research, Kaiser Permanente Northern California, Oakland, Calif.
⁴ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Partners Center for Personalized Medicine, Partners Health Care, Boston, Mass.
⁵ Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass; Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Mass.
⁶ Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pa.
⁷ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass. Electronic address: Ann.Wu@childrens.harvard.edu.

Abstract

In this large, multi-ethnic GWAS of asthma, we identified novel associations with potential functional relevance for asthma susceptibility in older adults of diverse racial backgrounds.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Adult
Asthma / ethnology
Asthma / genetics*
Female
Genetic Predisposition to Disease / ethnology
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study
Genotype
Humans
Male
Polymorphism, Single Nucleotide

Abstract

Publication types

MeSH terms

Grants and funding