Identification of DNA methylation module in seasonal allergic rhinitis

Int J Pediatr Otorhinolaryngol. 2019 Feb;117:163-166. doi: 10.1016/j.ijporl.2018.11.030. Epub 2018 Nov 29.

Abstract

Objective: In this study, we aimed to characterize the significant DNA methylation module of seasonal allergic rhinitis.

Methods: Methylation profiling E-GEOD-50222 was obtained from ArrayExpress database. Differential co-methylation network (DCN) was constructed based on the methylation data. From the DCN, we characterized multiple differential modules (M-DMs). Significant module was mapped to pathways to identify significant enriched pathways.

Results: At the criteria of absolute Pearson coefficient value > 0.8, the edges were chose to construct DCN. In the DCN, 16 seed genes were identified. Seed genes were used to construct M-DMs. After statistical analysis, one significant module with p < 0.05 were obtained. After pathways enrichment analysis, 17 significant pathways with p < 0.05 were obtained, and most of these pathways were associated with DNA replication.

Conclusion: One multiple differential module was identified in SAR, and seventeen significant pathways mapped by the module were identified as important factors in SAR. These results may provide new insights into the molecular mechanism of DNA methylation in SAR.

Keywords: DNA methylation; Network; Pathway; Seasonal allergic rhinitis.

MeSH terms

  • DNA Methylation*
  • Databases, Genetic
  • Gene Regulatory Networks
  • Humans
  • Rhinitis, Allergic, Seasonal / genetics*