Central Diabetes Insipidus in an Infant With Pneumococcal Meningitis

Fetal Pediatr Pathol. 2019 Feb;38(1):80-84. doi: 10.1080/15513815.2018.1547335. Epub 2018 Dec 22.


Background: Central diabetes is an infrequent complication reported in the neonatal period.

Case report: CDI as a complication of Streptococcus pneumoniae (S. pneumoniae) sepsis and meningitis in a 9-day-old boy is presented. The CDI developed on day 3 after admission and was controlled with nasal vasopressin on the 20th day of admission. Despite antibiotic support, the child died from Acinetobacter sepsis at 4 months of age, but the CDI was well controlled.

Conclusion: Newborns with bacterial meningitis can develop CDI as a sequalae. Treatment of the CDI with nasal vasopressin can be successful in this period. To our knowledge, this is the first newborn of CDI associated with S. pneumoniae meningitis.

Keywords: central diabetes insipidus; meningitis; newborn.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intranasal
  • Antidiuretic Agents / administration & dosage
  • Diabetes Insipidus, Neurogenic / drug therapy
  • Diabetes Insipidus, Neurogenic / etiology*
  • Fatal Outcome
  • Humans
  • Infant, Newborn
  • Male
  • Meningitis, Pneumococcal / complications*
  • Vasopressins / administration & dosage


  • Antidiuretic Agents
  • Vasopressins