Plasma Cell-Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients

Open Forum Infect Dis. 2018 Nov 16;5(12):ofy301. doi: 10.1093/ofid/ofy301. eCollection 2018 Dec.


Allogeneic hematopoietic stem cell transplant patients are at risk for common and atypical infections. Superior diagnostics can decrease infection-related morbidity and mortality. A novel plasma cell-free DNA next-generation sequencing test detected an uncommon presentation of Chlamydia trachomatis and recurrent and metastatic complications of Staphylococcus aureus bacteremia before standard microbiology.

Keywords: immunocompromised; molecular diagnostics; next-generation sequencing; stem cell transplant.