The safety of lanreotide for neuroendocrine tumor

Expert Opin Drug Saf. 2019 Jan;18(1):1-10. doi: 10.1080/14740338.2019.1559294. Epub 2018 Dec 24.


Lanreotide autogel is a synthetic somatostatin analogue which has been FDA and EMA approved for unresectable, well to moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumor. Its action is mediated by its affinity to somatostatin receptors, especially sst2 and sst5 receptors. Its longer half-life offers the convenience of 4-week dosing over the need for frequent injections of short-acting somatostatin analogues. Areas covered: Lanreotide ATG offers progression-free survival benefit in locally advanced or metastatic neuroendocrine tumor (NET) compared to placebo, reflecting a strong antiproliferative signal. As lanreotide is commonly used for management of NET, it is imperative to recognize and appropriately manage any drug-related toxicities. In this review, we will provide an overview of the toxicity with lanreotide and its management. Expert opinion: Lanreotide is highly effective in managing carcinoid symptoms and has a robust anti-tumor effect in NET. Overall, it is well tolerated with low rates of treatment discontinuation due to toxicity. It's toxicity profile is mostly predictable, and patients should be informed of the transient nature of some of the upfront toxicities.

Keywords: Gastroenteropancreatic neuroendocrine tumors (GEP-NET); lanreotide; somatostatin.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / pharmacology
  • Disease-Free Survival
  • Humans
  • Intestinal Neoplasms / drug therapy*
  • Intestinal Neoplasms / pathology
  • Neuroendocrine Tumors / drug therapy*
  • Neuroendocrine Tumors / pathology
  • Pancreatic Neoplasms / drug therapy*
  • Pancreatic Neoplasms / pathology
  • Peptides, Cyclic / administration & dosage*
  • Peptides, Cyclic / adverse effects
  • Peptides, Cyclic / pharmacology
  • Somatostatin / administration & dosage
  • Somatostatin / adverse effects
  • Somatostatin / analogs & derivatives*
  • Somatostatin / pharmacology
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology


  • Antineoplastic Agents
  • Peptides, Cyclic
  • lanreotide
  • Somatostatin

Supplementary concepts

  • Gastro-enteropancreatic neuroendocrine tumor