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Review
, 25 (1), e3141

Inverse Electron Demand Diels-Alder (IEDDA) Reactions in Peptide Chemistry

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Review

Inverse Electron Demand Diels-Alder (IEDDA) Reactions in Peptide Chemistry

Mareen Pagel. J Pept Sci.

Abstract

Click chemistry is applied to selectively modify, lable and ligate peptides for their use as therapeutics, in biomaterials or analytical investigations. The inverse electron demand Diels-Alder (IEDDA) reaction is a catalyst-free click reaction with pronounced chemoselectivity and fast reaction rates. Applications and achievements of the IEDDA reaction in peptide chemistry since 2008 are described in this review.

Keywords: DARinv; IEDDA; click chemistry; peptides; tetrazine.

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