The Effect of Lipopolysaccharide-containing Moisturizing Cream on Skin Care in Patients With Mild Atopic Dermatitis

In Vivo. 2019 Jan-Feb;33(1):109-114. doi: 10.21873/invivo.11446.


Background/aim: Recently, the prevalence of atopic dermatitis (AD) has increased in developed countries. This study aimed to examine the usefulness of a moisturizing cream containing lipopolysaccharide derived from Pantoea agglomerans (LPSp) in patients with mild AD.

Patients and methods: A moisturizing cream containing LPSp or its placebo was randomly assigned and continuously used for 4 weeks in patients with mild AD. AD severity was evaluated in a double-blind manner by a dermatologist using the Eczema Area and Severity Index (EASI) score and by the patients' self-evaluation of itching and skin condition using a visual analog scale (VAS).

Results: Although there was no difference in the EASI score between the two groups, the VAS scores showed significantly greater symptom alleviation in the LPSp group than in the placebo group.

Conclusion: A moisturizing cream containing LPSp may be effective for routine skin care and could help alleviate symptoms of mild AD.

Keywords: LPS; Skin; innate immunity; itching.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / physiopathology
  • Double-Blind Method
  • Female
  • Humans
  • Immunity, Innate / drug effects*
  • Lipopolysaccharides / administration & dosage*
  • Lipopolysaccharides / immunology
  • Male
  • Middle Aged
  • Severity of Illness Index
  • Skin Care / methods*
  • Skin Cream / administration & dosage
  • Treatment Outcome


  • Lipopolysaccharides