Inflammation and pancreatic cancer: An updated review

Saudi J Gastroenterol. 2019 Jan-Feb;25(1):3-13. doi: 10.4103/sjg.SJG_390_18.

Abstract

Pancreatic cancer is a devastating disease with poor prognosis in the modern era. Inflammatory processes have emerged as key mediators of pancreatic cancer development and progression. Recently, studies have been carried out to investigate the underlying mechanisms that contribute to tumorigenesis induced by inflammation. In this review, the role of inflammation in the initiation and progression of pancreatic cancer is discussed.

Keywords: Inflammation; pancreatic cancer; tumorigenesis.

Publication types

  • Review

MeSH terms

  • Adenoma
  • Antigen-Antibody Complex / metabolism
  • Autophagy / genetics
  • Carcinogenesis / metabolism
  • Carcinogenesis / pathology
  • Chemokine CXCL12 / metabolism
  • Cyclooxygenase 2 / metabolism
  • DNA-Binding Proteins / metabolism
  • Disease Progression
  • Humans
  • Inflammation / complications*
  • Inflammation / metabolism
  • Inflammation / pathology
  • Inflammation Mediators / metabolism
  • Interleukins / metabolism
  • Pancreatic Neoplasms / epidemiology*
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology
  • Pancreatitis, Chronic / complications*
  • Pancreatitis, Chronic / epidemiology
  • Pancreatitis, Chronic / genetics
  • Reactive Oxygen Species / metabolism
  • Toll-Like Receptors / metabolism
  • Transforming Growth Factor beta / metabolism
  • Trypsin Inhibitor, Kazal Pancreatic / genetics
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Antigen-Antibody Complex
  • Chemokine CXCL12
  • DNA-Binding Proteins
  • Inflammation Mediators
  • Interleukins
  • NFRKB protein, human
  • Reactive Oxygen Species
  • SPINK1 protein, human
  • Toll-Like Receptors
  • Transforming Growth Factor beta
  • Tumor Necrosis Factor-alpha
  • Trypsin Inhibitor, Kazal Pancreatic
  • Cyclooxygenase 2

Supplementary concepts

  • Pancreatic adenoma