Haemophilus-Dominant Nasopharyngeal Microbiota Is Associated With Delayed Clearance of Respiratory Syncytial Virus in Infants Hospitalized for Bronchiolitis

J Infect Dis. 2019 May 5;219(11):1804-1808. doi: 10.1093/infdis/jiy741.


The relation of nasopharyngeal microbiota to the clearance of respiratory syncytial virus (RSV) in infants hospitalized for bronchiolitis is not known. In a multicenter cohort, we found that 106 of 557 infants (19%) hospitalized with RSV bronchiolitis had the same RSV subtype 3 weeks later (ie, delayed clearance of RSV). Using 16S ribosomal RNA gene sequencing and a clustering approach, infants with a Haemophilus-dominant microbiota profile at hospitalization were more likely than those with a mixed profile to have delayed clearance, after adjustment for 11 factors, including viral load. Nasopharyngeal microbiota composition is associated with delayed RSV clearance.

Keywords: Airway microbiota; bronchiolitis; children; infant; microbiome; respiratory infection; respiratory syncytial virus.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Bronchiolitis / microbiology*
  • Female
  • Haemophilus / growth & development*
  • Hospitalization
  • Humans
  • Infant
  • Male
  • Microbiota*
  • Nasopharynx / microbiology
  • Nasopharynx / virology
  • Respiratory Syncytial Virus Infections / virology
  • Respiratory Syncytial Virus, Human / immunology*
  • Viral Load