The SMILES trial: do undisclosed recruitment practices explain the remarkably large effect?

BMC Med. 2018 Dec 28;16(1):243. doi: 10.1186/s12916-018-1221-5.


The SMILES trial showed substantial improvement of depressive symptoms following seven consultations on healthy dieting. The very large effect size on depression reduction seems remarkable and we suggest that selectively induced expectancy and a loss of blinding have contributed to the observed effect.

Publication types

  • Letter
  • Comment

MeSH terms

  • Adult
  • Depression*
  • Depressive Disorder, Major*
  • Diet
  • Humans