In vitro and in vivo immunomodulatory effects of fucoidan compound agents

Int J Biol Macromol. 2019 Apr 15;127:48-56. doi: 10.1016/j.ijbiomac.2018.12.197. Epub 2018 Dec 26.


Fucoidan extracted from brown algae displays diverse biological activities. In the present study, fucoidan was mixed with Chinese herb extracts, and the in vitro and in vivo immunomodulatory effects of two fucoidan compound agents were evaluated. The results showed that fucoidan from Kjellmaniella crassifolia (KF) and Undaria pinnatifida (UF) were sulfated polysaccharides, Astragalus polysaccharide (AP) was composed of α-d-glucose, and Codonopsis pilosula polysaccharide (CPP) was a furanose. Furthermore, fucoidan compound agents stimulated mouse macrophage RAW264.7 cell proliferation and enhanced the secretion of granulocyte-macrophage colony stimulating factor (GM-CSF) and tumour necrosis factor-α (TNF-α) in vitro. In addition, KCA (KF + AP + CPP) and UCA (UF + AP + CPP) could improve the nonspecific immunity and the specific immunity of BALB/c mice. Fucoidan compound agents also increased the secretion of GM-CSF, TNF-α, interleukin (IL)-4 and IL-10 in vivo. Therefore, we confirmed that fucoidan compound agents have promise for development as supplementary immunopotentiators.

Keywords: Fucoidan compound agents; Immunomodulatory; In vitro; In vivo.

MeSH terms

  • Adaptive Immunity / drug effects*
  • Animals
  • Cytokines / immunology*
  • Drugs, Chinese Herbal* / chemistry
  • Drugs, Chinese Herbal* / pharmacology
  • Immunity, Innate / drug effects*
  • Immunologic Factors* / chemistry
  • Immunologic Factors* / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • Polysaccharides* / chemistry
  • Polysaccharides* / pharmacology
  • RAW 264.7 Cells


  • Cytokines
  • Drugs, Chinese Herbal
  • Immunologic Factors
  • Polysaccharides
  • fucoidan