Green recipes to quinoline: A review

Eur J Med Chem. 2019 Feb 15:164:121-170. doi: 10.1016/j.ejmech.2018.11.026. Epub 2018 Dec 21.

Abstract

The quinoline core possesses a vast number of biological activities such as anticancer, antimalarial, antimicrobial, antifungal, antitubercular and antileishmanial. The conventional classical synthetic methods require the use of expensive and harsh conditions such as high temperature. Currently the scientific communities are searching new methodology to eliminate the use of chemicals, solvents and catalysts, which are hazardous to human health as well as to environment. This review provides a concise overview of new dimensions of green chemistry approaches in designing quinoline scaffold that would encourage the researchers towards green chemistry as well as future application of these greener, non-toxic, environment friendly methods in designing quinoline scaffold.

Keywords: Friedländer reaction; Green chemistry; Microwave irradiation; Multicomponent reactions; Quinolines.

Publication types

  • Review

MeSH terms

  • Drug Design
  • Green Chemistry Technology / methods*
  • Green Chemistry Technology / trends
  • Humans
  • Quinolines / chemical synthesis*
  • Quinolines / therapeutic use

Substances

  • Quinolines