Neural histology and neurogenesis of the human fetal and infant brain

Neuroimage. 2019 Mar;188:743-773. doi: 10.1016/j.neuroimage.2018.12.043. Epub 2018 Dec 27.


The human brain develops slowly and over a long period of time which lasts for almost three decades. This enables good spatio-temporal resolution of histogenetic and neurogenetic events as well as an appropriate and clinically relevant timing of these events. In order to successfully apply in vivo neuroimaging data, in analyzing both the normal brain development and the neurodevelopmental origin of major neurological and mental disorders, it is important to correlate these neuroimaging data with the existing data on morphogenetic, histogenetic and neurogenetic events. Furthermore, when performing such correlation, the genetic, genomic, and molecular biology data on phenotypic specification of developing brain regions, areas and neurons should also be included. In this review, we focus on early developmental periods (form 8 postconceptional weeks to the second postnatal year) and describe the microstructural organization and neural circuitry elements of the fetal and early postnatal human cerebrum.

Keywords: Cerebral cortex; Human brain development; Subplate; Telencephalon.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / cytology*
  • Brain / growth & development*
  • Child Development*
  • Child, Preschool
  • Fetal Development*
  • Humans
  • Infant
  • Infant, Newborn
  • Neurogenesis*