Transcriptome protection by the expanded family of hnRNPs

Urmi Das; Hai Nguyen; Jiuyong Xie

doi:10.1080/15476286.2018.1564617

Transcriptome protection by the expanded family of hnRNPs

RNA Biol. 2019 Feb;16(2):155-159. doi: 10.1080/15476286.2018.1564617. Epub 2019 Jan 6.

Authors

Urmi Das¹, Hai Nguyen^{1

2}, Jiuyong Xie¹

Affiliations

¹ a Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , Canada.
² b Department of Applied Computer Science , University of Winnipeg , Winnipeg , Canada.

Abstract

The family of heterogeneous ribonucleoproteins (hnRNPs) have multiple functions in RNA metabolism. In recent years, several hnRNPs have also been shown to be essential for the maintenance of transcriptome integrity, by preventing intronic cryptic splicing signals from mis-splicing of many endogeneous pre-mRNA transcripts. Here we discuss the possibility for a general role of this family of proteins and their expansion in transcriptome protection.

Keywords: Hnrnps; cryptic splicing; introns; transcriptome integrity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Binding Sites
Gene Expression Regulation*
Heterogeneous-Nuclear Ribonucleoproteins / genetics
Heterogeneous-Nuclear Ribonucleoproteins / metabolism*
Humans
Multigene Family*
Nucleotide Motifs
Protein Binding
RNA Precursors / genetics
RNA Precursors / metabolism
RNA Splicing
Transcription, Genetic*
Transcriptome*

Substances

Heterogeneous-Nuclear Ribonucleoproteins
RNA Precursors

Grants and funding

This work was supported by the Natural Sciences and Engineering Research Council of Canada [RGPIN-2016-06004]; Manitoba Research Chair Fund; University of Manitoba Graduate Fellowship; Research Manitoba.