Release of ciprofloxacin drugs by nano gold embedded cellulose grafted polyacrylamide hybrid nanocomposite hydrogels

Abstract

The present work involves the designing of the porous nano gold embedded cellulose grafted polyacrylamide (PAM/C/Au) nanocomposite hydrogel which has been prepared by in situ polymerization process with an objective of application for the in vitro release of ciprofloxacin drugs. The structure, composition, morphology behaviour of the nanocomposite hydrogels are explored using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction study (XRD), X-ray photoelectron spectroscopy (XPS); field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and atomic force microscopy (AFM). The thermal stability of the as synthesized nanocomposite hydrogels are studied by TGA. The gelling actions of prepared nanocomposite hydrogels are determined by the rheological study. The investigations of cytotoxicity tests and antibacterial behaviour along with negative and positive actions of nanocomposite hydrogels are investigated. The study of the release rate of ciprofloxacin drugs is carried out by measuring water retention and swelling properties of nanocomposite hydrogels. The in vitro release rate of ciprofloxacin antibiotic drug is found to be 96.6% in 5 h. The PAM/C/Au nanocomposite hydrogels with improved thermal and rheological properties are suitable proposed as a good carrier towards in vitro release of the ciprofloxacin drugs.

Keywords: Au NPs; Ciprofloxacin; In vitro; Nanocomposites hydrogels; Rheology.