Planting the Microbiome

Trends Microbiol. 2019 Feb;27(2):90-93. doi: 10.1016/j.tim.2018.12.001. Epub 2018 Dec 29.


Plant-derived microRNAs stabilized by species-specific lipid nanoparticles mediate interkingdom communication through bacterial intermediates and impact consumer health. Ingested by distinct gut bacteria, these microRNA-containing particles alter bacterial gene expression to affect host immunity. This three-kingdom interplay provides compelling approaches for health-directed dietary interventions for consumers.

Keywords: bacteria; exosome-like nanoparticles; microRNA; microbiome; plant.

MeSH terms

  • Bacteria / genetics
  • Bacteria / metabolism*
  • Exosomes
  • Gastrointestinal Microbiome / immunology*
  • Gastrointestinal Tract / microbiology
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial / genetics
  • Host Microbial Interactions / immunology
  • MicroRNAs / metabolism*
  • Nanoparticles
  • Plants / metabolism*


  • MicroRNAs