Non-invasive Analysis of Skin Mechanical Properties in Patients With Lamellar Ichthyosis

Skin Res Technol. 2019 May;25(3):375-381. doi: 10.1111/srt.12663. Epub 2019 Jan 2.


Background: Reliable methods for the quantitative evaluation of skin of patients with ichthyosis are critically needed. Our purpose was to evaluate the biomechanical parameters of skin in a cohort of patients with clinically diagnosed lamellar ichthyosis.

Materials and methods: Twenty-two patients diagnosed with lamellar ichthyosis were studied. Ichthyosis plaques located in upper distal limbs were assayed, and a nearby anatomical region without plaques from the same patient was employed as control. Skin biomechanical properties were studied through a non-invasive device (Cutometer® MPA 580).

Results: Ichthyosis plaques had higher values for the Uf-Ua parameter and lower values for the Ua/Uf, Ur/Ue, and Ur/Uf parameters. Adults and children showed similar statistical differences. There were no significant differences in data from men, whereas in women differences for all of the parameters were found. There was a significant decrease in the hydration and an increase in melanin index in the ichthyosis plaques.

Conclusion: Our results suggest that analysis of parameters Uf-Ua, Ua/Uf, Ur/Ue, Ur/Uf, hydration, and melanin index could be employed for quantitative monitoring of skin. Therefore, the non-invasive method applied may be suitable for evaluation of skin of patients with ichthyosis in response to medical treatments.

Keywords: cutometer; elasticity; erythema; hydration; ichthyosis; melanin; skin.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomechanical Phenomena / physiology
  • Child
  • Child, Preschool
  • Elasticity
  • Female
  • Humans
  • Ichthyosis, Lamellar / pathology
  • Ichthyosis, Lamellar / physiopathology*
  • Infant
  • Male
  • Middle Aged
  • Skin / pathology*
  • Skin Physiological Phenomena*
  • Young Adult