Neutrophil Activation in Occupational Asthma

Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):81-85. doi: 10.1097/ACI.0000000000000507.

Abstract

Purpose of review: The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace.

Recent findings: Increased recruitment and infiltration of neutrophils are found in patients with occupational asthma. Activated neutrophils release several mediators including pro-inflammatory cytokines and extracellular traps, leading to stimulation of airway epithelium and other inflammatory cells.

Summary: New insights into neutrophils in the pathogenesis of occupational asthma may provide a novel approach to the individual patient with occupational asthma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Asthma, Occupational / diagnosis
  • Asthma, Occupational / immunology*
  • Cytokines / metabolism
  • Humans
  • Inflammation Mediators / metabolism
  • Neutrophil Activation*
  • Neutrophils / immunology*
  • Precision Medicine

Substances

  • Cytokines
  • Inflammation Mediators