Retina. 2020 Jan;40(1):80-86. doi: 10.1097/IAE.0000000000002435.


Purpose: To report a series of eight patients with perifoveal exudative vascular anomalous complex imaged with optical coherence tomography angiography and the results of anti-vascular endothelial growth factor therapy or laser photocoagulation.

Methods: Retrospective analysis of demographic data, imaging including color pictures, spectral domain optical coherence tomography, and optical coherence tomography angiography, and fluorescein angiography, course, and outcome.

Results: Age at onset ranged from 45 to 84 years (mean ± SD: 68.6 ± 13.7). Five cases were initially misdiagnosed. The perifoveal exudative vascular anomalous complex lesion was unique in seven eyes and located predominantly in the superficial capillary plexus in two eyes, strictly in the deep capillary plexus in two eyes, but observed at the level of both plexi (3 eyes). One patient presented two lesions, one in the superficial capillary plexus and one in the deep capillary plexus. Capillary rarefaction was observed around the lesion in six eyes. Sustainable resolution of exudation could be achieved in 2 patients, one after 2 sessions of focal thermal laser photocoagulation and one after 13 intravitreal injections of anti-vascular endothelial growth factor.

Conclusion: The present series confirms that perifoveal exudative vascular anomalous complex corresponds to a new entity that differs from other conditions associated with capillary aneurysmal lesions. Visual improvement could be obtained after treatment with focal laser or intravitreal anti-vascular endothelial growth factor agents.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aneurysm / pathology*
  • Aneurysm / physiopathology
  • Aneurysm / therapy
  • Angiogenesis Inhibitors / therapeutic use
  • Exudates and Transudates
  • Female
  • Fluorescein Angiography
  • Fovea Centralis / blood supply*
  • Humans
  • Intravitreal Injections
  • Laser Coagulation
  • Male
  • Middle Aged
  • Optical Imaging
  • Retinal Diseases / pathology*
  • Retinal Diseases / physiopathology
  • Retinal Diseases / therapy
  • Retinal Vessels / abnormalities*
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Vascular Malformations / pathology*
  • Vascular Malformations / physiopathology
  • Vascular Malformations / therapy
  • Visual Acuity / physiology


  • Angiogenesis Inhibitors
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A